Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology
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- 作者：Samantha E. Yohna ; Emily E. Errantea ; Aaron Rosenbloom-Snowa ; Matthew Somervillea ; Margaret Rowlanda ; Kristin Tokarskia ; Nadia Zafara ; Merce Correaa ; b ; John D. Salamonea ; john.salamone@uconn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dopamine ; Norepinephrine ; Serotonin ; Transport ; Motivation ; Depression
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：270-280
- 全文大小：693 K
文摘
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Effort-related choice tasks can be used to assess motivational effects of drugs.
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Rats were assessed using a progressive ratio/chow feeding choice task.
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The dopamine transport blocker GBR12909 increases exertion of effort.
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Blockers of 5-HT and norepinephrine transport do not.
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These results have implications for treating human motivational symptoms.