Cloning and comparative analysis the proximal promoter activities of arginase and agmatinase genes in Apostichopus japonicus
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- 作者：Yina Shaoa ; Chenghua Lia ; lichenghua@nbu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Weiwei Zhanga ; Wei Xub ; Xuemei Duana ; Ye Lia ; Qiongfen Qiua ; Chunhua Jina
- 关键词：Apostichopus japonicus ; Transcription factor ; Promoter activity ; LPS ; l-arginine ; Luciferase assay
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：299-308
- 全文大小：3386 K
文摘
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Promotor sequences of arginase and agmatinase genes were identified firstly in Apostichopus japonicus.
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Ajargianse and Ajagmatinase promoter activities were induced by LPS exposure and l-arginine treatment.
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The region −673/+25 and −648/+32 both contributed importantly to expression of the Ajargianse and Ajagmatinase, respectively.
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NF-κB/Rel and STAT5 could significantly inhibited Ajargianse promoter activity, but not Ajagmatinase.