MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death
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- 作者：Jee Y. Leea ; jeeyoun@hu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Hae Y. Choia ; neuron@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Tae Y. Yunea ; b ; tyune@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNS ; central nervous system ; COX-2 ; cyclooxygenase-2 ; iNOS ; inducible nitric oxide synthase ; IL ; interleukin ; KO ; knockout ; LPS ; lipopolysaccharide ; MMPs ; matrix metalloproteases ; NO ; nitric oxide ; OGD/RO ; oxygen glucose deprivation/reoxygenation ; p38MAPK ; p38 mitogen-activated protein kinase ; proNGF ; pro-nerve growth factor ; ROS ; reactive oxygen species ; SCI ; spinal cord injury ; TUNEL ; terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphatebiotin nick end labeling ; TNF-α ; tumor
- 刊名：Neurobiology of Disease
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：82
- 期：Complete
- 页码：141-151
- 全文大小：1536 K
文摘
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MMP-3 is expressed and secreted in hypoxia induced endothelial cells.
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MMP-3 is secreted in endothelial cells and mediates microglial activation.
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MMP-3 induces microglial activation and p38MAPK activation after SCI.
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Ghrelin inhibits MMP-3 expression and activity after SCI via GHS-R1a.