Gene expression profiling in breast cancer: A clinical perspective

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• 作者：Grazia Arpino^a ; ^{grazia.arpino@unina.it} ; Daniele Generaliⁱ ; Anna Sapino^b ; Del Matro Lucia^c ; Antonio Frassoldati^d ; Michelino de Laurentis^a ; Pronzato Paolo^c ; Giorgio Mustacchi^e ; Marina Cazzaniga^f ; Sabino De Placido^a ; Pierfranco Conte^d ; Mariarosa Cappelletti^h ; ⁱ ; Vanessa Zanoni^h ; ⁱ ; Andrea Antonelli^h ; ⁱ ; Mario Martinottiⁱ ; Fabio Puglisi^h ; Alfredo Berruti^g ; Alberto Bottiniⁱ ; Luigi Dogliotti^g
• 关键词：Breast cancer ; Gene arrays ; Gene profiles ; Prognostic factors
• 刊名：The Breast
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：22
• 期：2
• 页码：109-120
• 全文大小：347 K

文摘

Gene expression profiling tests are used in an attempt to determine the right treatment for the right person with early-stage breast cancer that may have spread to nearby lymph nodes but not to distant parts of the body. These new diagnostic approaches are designed to spare people who do not need additional treatment (adjuvant therapy) the side effects of unnecessary treatment, and allow people who may benefit from adjuvant therapy to receive it. In the present review we discuss in detail the major diagnostic tests available such as MammaPrint dx, Oncotype dx, PAM50, Mammostrat, IHC4, MapQuant DX, Theros-Breast Cancer Gene Expression Ratio Assay, and their potential clinical applications.