Interaction of lipids with the neurotensin receptor 1
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- 作者：Juan H. Bolivar ; Juan C. Muñ ; oz-Garcí ; a ; Tomas Castro-Dopico ; Patricia M. Dijkman ; Phillip J. Stansfeld ; Anthony Watts ; anthony.watts@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：CHS ; cholesterol hemisuccinate ; CHAPS ; 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate ; CSL ; 4&prime ; 4&prime ; -dimethylspiro(5α-cholestane-3 ; 2&prime ; -oxazolidin)-3&prime ; -yloxyl ; C14 ; 0PC ; 1 ; 2-dimyristoyl-sn-glycero-3-phosphocholine ; C15 ; 0PC ; 1 ; 2-dipentadecanoyl-sn-glycero-3-phosphocholine ; C16 ; 0&ndash ; C18 ; 1PC ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine ; C16 ; 0&ndash ; C18 ; 1PE ; (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine) ; C16 ; 0&ndash ; C18 ; 1PS ; (1-palmitoyl-2-oleoyl-sn-gly
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1858
- 期：6
- 页码：1278-1287
- 全文大小：801 K
文摘
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ESR of spin labelled lipids informs on lipid interactions with neurotensin receptor 1.
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10">The receptor is in an oligomeric state at low lipid:protein ratios.
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15">Relative lipid affinities for the receptor rank as follows: SA > PS > PE = PC = cholestane.
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MD simulations point to potential high affinity binding sites for PS.