Biochemical bone turnover markers in diabetes mellitus — A systematic review
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- 作者：Jakob Starup-Lindea ; b ; jakolind@rm.dk" class="auth_mail" title="E-mail the corresponding author ; Peter Vestergaardb ; c
- 关键词：25 OHD ; 25 hydroxy vitamin D ; BMD ; bone mineral density ; BAP ; bone specific alkaline phosphatase ; BTM ; bone turnover marker ; PICP ; carboxy-terminal propeptide of type I procollagen ; CICP ; collagen type 1C propeptide ; CTX ; C-terminal cross-link of collagen ; DPD ; deoxypyridinoline ; HP ; hydroxyproline ; IDDM ; insulin dependent diabetes mellitus ; IGF-1 ; insulin-like growth factor-1 ; IVGTT ; intravenous glucose tolerance test ; NTX ; N-terminal propeptide type 1 collagen ; OGTT ; oral glucose tolerance tes
- 刊名：Bone
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：82
- 期：Complete
- 页码：69-78
- 全文大小：407 K
文摘
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Markers of bone resorption and formation seem to be lower in diabetes patients.
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C-terminal cross-link of collagen, insulin-like growth factor-1, and sclerostin may potentially predict fractures.
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47 studies were included among these 1 meta-analysis, 29 cross-sectional studies, 13 randomized controlled trials, and 4 longitudinal studies.
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Bone turnover in diabetes patients may fluctuate depending on the glucose level.
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Longitudinal studies evaluating bone turnover markers and fractures in diabetes patients are needed.