Survival outcomes and incidence of brain recurrence in high-grade neuroendocrine carcinomas of the lung: Implications for clinical practice
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- 作者：Giulio Metroa ; Biagio Ricciutia ; biagio.ricciuti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Rita Chiaria ; Marina Barettib ; Lorenzo Falcinellic ; Diana Giannarellid ; Angelo Sidonie ; Giannis Mountziosf ; Lucio Crinò ; a ; Guido Bellezzae ; Alberto Rebonatog ; Piero Ferollaa ; Luca Toschib
- 关键词：Chemotherapy ; High-grade neuroendocrine carcinoma of the lung ; Large cell neuroendocrine carcinoma of the lung ; Platinum-etoposide ; Prophylactic cranial irradiation ; Small cell lung cancer
- 刊名：Lung Cancer
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：82-87
- 全文大小：733 K
文摘
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Treatment of advanced LCNECs of the lung is not well established.
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Advanced LCNECs treated with platinum/etoposide ± thoracic RT bear a poor prognosis.
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Stage III and IV LCNECs have a rate of brain recurrence of 58% and 48% at 18 months.
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Whether PCI may reduce brain recurrence over time should be prospectively assessed.