Comparison of flunarizine and topiramate for the prophylaxis of pediatric migraines

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• 作者：Hunmin Kim^a ; Sung Hwan Byun^b ; Jon Soo Kim^a ; Byung Chan Lim^b ; Jong-Hee Chae^b ; Jieun Choi^c ; Ki Joong Kim^b ; Yong Seung Hwang^b ; Hee Hwang^a ; ^{neuroandy@snubh.org}
• 关键词：Topiramate ; Flunarizine ; Migraine prophylaxis ; Pediatric
• 刊名：European Journal of Paediatric Neurology
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：17
• 期：1
• 页码：45-49
• 全文大小：228 K

文摘

The purpose of this study was to compare the efficacy and tolerability of topiramate and flunarizine for the prophylaxis of pediatric migraines. A retrospective medical-record review of patients who underwent prophylaxis after receiving a diagnosis of migraine with aura and without aura was performed. Only patients who completed at least 3 months of treatment were included in the analysis. Response to treatment was assessed as the total number of headache days/month. Patients with more than 50 % reduction in headache days/month were classified as responders. Responder rate, retention rate, and adverse-event rates were also calculated from all patients who started on the prophylaxis. Further analyses were performed using different patient groups with a cut-off age of 12 years. The responder rate was 80 % (89/111 patients) for flunarizine and 81 % (122/150 patients) for topiramate, based on a comparison among 261 patients. The retention rate was 67 % for flunarizine and 63 % for topiramate and the adverse-event rate was 6 % for flunarizine and 10 % for topiramate. The responder rate, the retention rate, and the adverse-event rate were not significantly different between flunarizine and topiramate. These findings were concordant between the preadolescent (6-12 years old) and adolescent (13-18 years old) groups. The efficacy and tolerability of topiramate were not inferior to those of flunarizine for the prophylaxis of pediatric migraines. These findings were observed in preadolescent and adolescent patients.