Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells
刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:February 2017
年:2017
卷:1863
期:2
页码:414-427
全文大小:2632 K
卷排序:1863
文摘
Zn2 + enhances Tau aggregation in neuronal cells. Zn2 + enhances Tau aggregation-induced apoptosis and toxicity in neuronal cells. Substitution of two cysteine residues in Tau eliminates such enhancing effects. Our findings link Tau aggregation and toxicity regulated by zinc to the pathogenesis of Alzheimer disease.