Climbing fibers in spinocerebellar ataxia: A mechanism for the loss of motor control
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- 作者：C.J.L.M. Smeets ; D.S. Verbeek ; d.s.verbeek@umcg.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; α-amino-3-hydroxy-5-methylisoxazole-4-propionate ; CB1R ; type 1 cannabinoid receptor ; Cbln-1 ; precerebellin ; CF-LTD ; climbing fiber long term depression ; CF-PC ; climbing fiber-Purkinje cell ; E ; embryonic day ; LTD ; long term depression ; LTP ; long term potentiation ; P ; postnatal day ; PC ; Purkinje cell ; PF-LTD ; parallel fiber long term depression ; PF-LTP ; parallel fiber long term potentiation ; PF-PC ; parallel fiber-Purkinje cell ; NMDA ; N-methyl-D-aspartate ; NO ; nitric oxide ; NSF ; N-ethyl-malei
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：96-106
- 全文大小：690 K
文摘
The spinocerebellar ataxias (SCAs) form an ever-growing group of neurodegenerative disorders causing dysfunction of the cerebellum and loss of motor control in patients. Currently, 41 different genetic causes have been identified, with each mutation affecting a different gene. Interestingly, these diverse genetic causes all disrupt cerebellar function and produce similar symptoms in patients. In order to understand the disease better, and define possible therapeutic targets for multiple SCAs, the field has been searching for common ground among the SCAs. In this review, we discuss the physiology of climbing fibers and the possibility that climbing fiber dysfunction is a point of convergence for at least a subset of SCAs.