NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection
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- 作者：Jane E. Libbeya ; Tyler J. Hanaka ; Daniel J. Dotya ; Karen S. Wilcoxb ; Robert S. Fujinamia ; Robert.Fujinami@hsc.utah.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate ; ANOVA ; Analysis of variance ; ASDs ; anti-seizure drugs ; CNQX ; 6-cyano-7-nitroquinoxaline-2 ; 3-dione ; CNS ; central nervous system ; DA ; Daniels ; GABA ; γ-aminobutyric acid ; GFAP ; glial fibrillary acidic protein ; GYKI-52466 ; 1-(4-aminophenyl)-4-methyl-7 ; 8-methylenedioxy-5H-2 ; 3-benzodiazepine ; GYKI-53655 ; 1-(4-aminophenyl)-3-methylcarbamyl-4-methyl-7 ; 8-methylenedioxy-3 ; 4-dihydro-5H-2 ; 3-benzodiazepine ; i.c. ; intracerebrally ; i.p. ; intraperitoneal
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：280
- 期：Complete
- 页码：89-96
- 全文大小：758 K
文摘
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Upregulation of glutamate receptors can contribute to seizures.
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NBQX is a highly selective competitive antagonist of AMPA/KA glutamate receptors.
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NBQX had an effect on acute seizure development in the virus-induced seizure model.
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NBQX treatment resulted in a greater seizure burden, both incidence and severity.
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NBQX, a potent anticonvulsant, has the opposite effect on virus-induced seizures.