Effects of Bisphenol A on ion channels: Experimental evidence and molecular mechanisms
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- 作者：Sergi Sorianoa ; Cristina Ripollb ; Paloma Alonso-Magdalenac ; Esther Fuentesb ; Ivan Quesadab ; Angel Nadalb ; nadal@umh.es" class="auth_mail" title="E-mail the corresponding author ; Juan Martinez-Pinnaa ; juan.martinez-pinna@ua.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate ; BPA ; Bisphenol A ; ER ; estrogen receptor ; CFTR ; cystic fibrosis transmembrane conductance regulator ; GABAA ; gamma-aminobutyric acid type A ; EDCs ; endocrine-disrupting chemicals ; GPR30 or GPER ; G-protein coupled receptor 30 or G-protein coupled estrogen receptor ; HEK ; human embryonic kidney cells ; ICRAC ; Ca2+ release-activated currents ; NMDA ; N-methyl-d-aspartate ; o ; p&prime ; -DDT ; 4-octylphenol p-nonylphenol dichlorodiphenyltrichloroethane
- 刊名：Steroids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：12-20
- 全文大小：431 K
文摘
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The effects of Bisphenol A (BPA) on ion channels are reviewed.
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BPA experimental concentrations ranged from environmentally relevant to high doses.
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The function of a plethora of ion channels is affected by BPA.
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More studies are needed to unravel the health related actions of BPA on ion channels.