Localization of 14-3-3未/尉 on the neuronal cell surface
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- 作者：Yasuhiro Yamamoto1 ; Hiromi Koma1 ; Tatsurou Yagami ; yagami@himeji-du.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：A尾 ; amyloid 尾 ; AD ; Alzheimer's disease ; 15d-PGJ2 ; 15-deoxy-螖12 ; 14- prostaglandins J2 ; DP2 ; Type 2 receptor for prostaglandin D2 ; ERK ; extracellular signal-regulated kinase ; JNK ; c-Jun N-terminal kinase ; MAPK ; mitogen-activated protein kinase ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyl tetrazolium bromide dye ; NFTs ; neurofibrillary tangles ; p38-MAPK ; p38-mitogen activated protein kinase ; PPAR纬 ; peroxysome-proliferator activated receptor 纬 ; ROS ; reactive oxygen species
- 刊名：Experimental Cell Research
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：338
- 期：2
- 页码：149-161
- 全文大小：4145 K
文摘
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14-3-3未/尉 was localized to cell surface in the primary culture of cortical neurons.
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Anti-14-3-3未/尉 antibody induced neuronal cell death via H2O2.
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Catalase suppressed the antibody-generated H2O2.
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Catalase inhibited the neurotoxicity of anti-14-3-3未/尉 antibody.
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c-Jun N-terminal kinase partially contributed to the neurotoxicity.