Stromal COX-2 signaling are correlated with colorectal cancer: A review
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- 作者：Chen-Wei Sua ; Yuan Zhangb ; Ying-Ting Zhu ; Ph.D.a ; yzhu@tissuetechinc.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：COX-2 ; prostaglandin-endoperoxide synthase 2 ; PG ; prostaglandin ; GSK-3β ; glycogen synthase kinase 3β ; 15-d-PGJ₂ ; 15-deoxy-delta(12 ; 14)-prostaglandin J(2) ; PPARγ ; peroxisome proliferator-activated receptor gamma ; TNF-α ; tumor necrosis factor alpha ; IL-1β ; interleukin 1β ; DCA ; deoxycholic acid ; HGF ; hepatocyte growth factor ; PKC1 ; protein kinase C1 ; PI3 Kinase ; phosphoinositide 3-kinase ; Raf/MEK/ERK ; Ras-Raf-MEK-ERK pathway ; EGR-1 ; early growth response protein 1 ; Cyclin D1 ; cyclin D1 prote
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：33-38
- 全文大小：828 K
文摘
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COX-2 signaling plays a major role in development and progression of colorectal cancer.
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10">Stromal fibroblasts are a major source of COX-2 and PGE2.
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15">Stromal-epithelial interaction mediated by COX-2 signaling promotes colorectal carcinogenesis.
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Inhibition of stromal COX-2 signaling is necessary to control colorectal cancer.