Prostaglandin D2 elicits the reversible neurite retraction in hypothalamic cell line
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- 作者：Hiroyoshi Tsuchiyaa ; 1 ; tutty@jichi.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hirofumi Hohjohb ; 1 ; Yoko Fujiwaraa ; Yukihiko Sugimotob ; Taka-aki Koshimizua
- 关键词：PGD2 ; 15d-PGJ2 ; Neurite retraction ; ROS
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 February 2016
- 年：2016
- 卷：470
- 期：4
- 页码：804-810
- 全文大小：1253 K
文摘
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In mouse hypothalamic cell line, serum starvation induced neurite outgrowth.
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Prostaglandin (PG) D2 elicited reversible neurite retraction.
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The effect of PGD2 was inhibited by N-acetyl cysteine but not by a PPARγ antagonist.
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The effect of PGD2 was mimicked by 15-deoxy-Δ12,14-prostaglandin J2.