Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation
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- 作者：Tetsuro Ishii ; ishiitetsuro305@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; arachidonic acid ; AP-1 ; activator protein-1 ; ARE ; antioxidant-response element ; BMDM ; bone marrow-derived macrophage ; COX-2 ; cyclooxygenase-2 ; DEX ; dexamethasone ; 15d-PGJ2 ; 15-deoxy-螖12 ; 14-prostaglandin J2 ; ERK2 ; extracellular-regulated kinase 2 ; GST ; glutathione S-transferase ; HO-1 ; heme oxygenase-1 ; IL-1尾 ; interleukin 1尾 ; Keap1 ; Kelch-like ECH-associated protein ; H-PGDS ; hematopoietic prostaglandin D synthase ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; L-PGDS ; li
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：88
- 期：part_PB
- 页码：189-198
- 全文大小：1703 K
文摘
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15d-PGJ2 is an important intrinsic Nrf2 activator.
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Nrf2 regulates the expression of lipocalin-type prostaglandin D synthase.
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Peroxiredoxin 1 is secreted by exosomes under mild oxidation.
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Peroxiredoxin 6 activates NOX2 after phosphorylation by MAPKs.
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NOX2 enhances hematopoietic PGD synthase activity.