Alterations in antioxidant/oxidant gene expression and proteins following treatment of transformed and normal colon cells with tellurium compounds
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- 作者：Puneet Vij ; Diane Hardej ; hardejd@stjohns.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Te ; Tellurium ; ROS ; Reactive oxygen species ; GPx ; Glutathione peroxidase ; CAT ; Catalase ; ICP-OES ; Inductively Coupled Plasma-Optical Emission Spectroscopy ; O2&minus ; Superoxide anion ; H2O2 ; Hydrogen peroxide ; HO ; hydroxyl radical ; Nrf2 ; Nuclear factor erythroid 2-related factor 2 ; GSR ; Glutathione reductase ; SOD ; Superoxide dismutase ; PTGS-2 ; Prostaglandin synthase-2 ; COX-2 ; cyclooxygenase-2 ; HNE ; 4-hydroxy-2-nonenal ; NQO1 ; NADPH quinone oxidoreductase 1 ; MT ; Metallothionein ; ELISA ; Enzyme link
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：216-224
- 全文大小：633 K
文摘
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Exposure of HT-29 and CCD-18Co cells to DPDT and TeCl4 causes Te accumulation.
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10">Te treatment of HT-29 & CCD-18Co cells induces HO-1 confirming oxidative stress.
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15">Te treatment of HT-29 & CCD-18Co cells shows varied gene alterations.