刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:556-562
全文大小:1179 K
卷排序:482
文摘
c-myc binds to three E-box elements in the promoter region of mPGES1 and induces the transcription of this gene. Mutation of the proximal c-myc binding site results in considerable decrease in the promoter activity. Transfection of increasing concentrations of c-myc increases the production of PGE2. Isocoumarin analogs and Licofelone inhibit the mRNA expressions of both c-myc and mPGES1 and the production of PGE2.