An electrochemical biosensor to simultaneously detect VEGF and PSA for early prostate cancer diagnosis based on graphene oxide/ssDNA/PLLA nanoparticles
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- 作者：Lung-Hsuan Pana ; Shin-Hung Kuob ; Tzu-Yang Lina ; Chih-Wen Linc ; Po-Yu Fangd ; Hung-Wei Yanga ; howardyang@mail.nsysu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Graphene oxide ; Single strand DNA ; Vascular endothelial growth factor (VEGF) ; Prostate-specific antigen (PSA) ; Electrochemical biosensor ; Prostate cancer (PCa)
- 刊名：Biosensors and Bioelectronics
- 出版年：2017
- 出版时间：15 March 2017
- 年：2017
- 卷：89
- 期：part_P1
- 页码：598-605
- 全文大小：243 K
文摘
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Novel GO-ssDNA based biosensor incorporated with dual-antibody modified PLLA NPs.
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Simultaneous detection of VEGF and PSA in same one electrochemical biosensor.
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Achieving wide linear range of detection of 0.05–100 (VEGF) and 1–100 ng/mL (PSA).
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Highly sensitive and selective detection of VEGF and PSA was achieved in human serum.