Retinal stimulation strategies to restore vision: Fundamentals and systems

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• 作者：Lan Yue^a ; ¹ ; ^{lyue@usc.edu" class="auth_mail" title="E-mail the corresponding author} ; James D. Weiland^a ; ¹ ; Botond Roska^b ; ^c ; ¹ ; Mark S. Humayun^a ; ¹
• 关键词：Vision restoration ; Retinal stimulation ; Photoreceptor degeneration ; Prosthesis ; Bioelectronic ; Optogenetics ; Photoswitches ; Ultrasound
• 刊名：Progress in Retinal and Eye Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：53
• 期：Complete
• 页码：21-47
• 全文大小：4193 K

文摘

Retinal degeneration, a leading cause of blindness worldwide, is primarily characterized by the dysfunctional/degenerated photoreceptors that impair the ability of the retina to detect light. Our group and others have shown that bioelectronic retinal implants restore useful visual input to those who have been blind for decades. This unprecedented approach of restoring sight demonstrates that patients can adapt to new visual input, and thereby opens up opportunities to not only improve this technology but also develop alternative retinal stimulation approaches. These future improvements or new technologies could have the potential of selectively stimulating specific cell classes in the inner retina, leading to improved visual resolution and color vision. In this review we will detail the progress of bioelectronic retinal implants and future devices in this genre as well as discuss other technologies such as optogenetics, chemical photoswitches, and ultrasound stimulation. We will discuss the principles, biological aspects, technology development, current status, clinical outcomes/prospects, and challenges for each approach. The review will cover functional imaging documented cortical responses to retinal stimulation in blind patients.