In vivo imaging of protease activity by Probody therapeutic activation
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- 作者：Kenneth R. Wonga ; Elizabeth Menendeza ; Charles S. Craikb ; W. Michael Kavanaugha ; Olga Vasiljevaa ; olga@cytomx.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protease activity ; Monoclonal antibody ; In vivo imaging ; Tumor targeting
- 刊名：Biochimie
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：62-67
- 全文大小：1163 K
文摘
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A novel approach for profiling protease activity in living animals is described.
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Method uses Probody therapeutics and avoids limitations of directly labeled reagents.
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Validity of method was confirmed by administering a specific protease inhibitor in vivo.