A novel histochemical method for the visualization of thrombin activity in the nervous system
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- 作者：D. Bushia ; b ; &dagger ; ; doron.bushi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; O. Geraa ; b ; g ; &dagger ; ; G. Kosteniche ; E. Shavit-Steina ; R. Weissa ; f ; J. Chapmana ; b ; c ; d ; &Dagger ; ; D. Tannea ; c ; &Dagger ;
- 关键词：4MβNA ; 4-methoxy-2-naphthylamine ; BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; MCAo ; middle cerebral artery occlusion ; mTBI ; minimal traumatic brain injury ; NAPAP ; Nα-(2-Naphthylsulfonylglycyl)-4-Amidino-(D ; L)-Phenylalanine Piperidide Acetate ; NSA ; 5-nitrosalicylaldehyde ; OGD ; oxygen glucose deprivation ; PAR1 ; proteases-activated receptor 1 ; PBS ; phosphate-buffered saline ; tMCAo ; transient middle cerebral artery occlusion ; TTC ; triphenyltetrazolium chloride
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：320
- 期：Complete
- 页码：93-104
- 全文大小：3844 K
文摘
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We have developed a new histochemical method for visualizing the location of thrombin activity in the nervous system.
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10">The topographic distribution of thrombin activity in mouse brain following ischemic stroke is demonstrated.
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15">The distribution of thrombin activity is in good correlation with the infarct areas.
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Focal areas of highly elevated thrombin activity are detected in teased sciatic fibers following crush injury.