Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4ADCAF1 to promote colon cancer development
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- 作者：Weiguo Rena ; b ; c ; Shourong Shena ; b ; Zhenqiang Sunc ; Peng Shua ; Xiaohua Shena ; Chibin Bua ; Feiyan Aia ; b ; Xuemei Zhangc ; Anliu Tanga ; b ; Li Tiana ; b ; Guiyuan Lib ; c ; Xiayu Lia ; b ; lixiayu@163.com" class="auth_mail" title="E-mail the corresponding author ; Jian Maa ; b ; c ; majian@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：DICER1 ; CUL4ADCAF1 ligase complex ; Jak-STAT3 ; Ubiquitination ; Colon cancer ; IL-6
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：375
- 期：2
- 页码：209-220
- 全文大小：5096 K
文摘
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Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by CUL4ADCAF1.
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DICER1 and p-STAT3 expression has close correlation in colon cancer.
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Lower DICER1 expression in colon cancer correlates with poor survival.