Orobol derivatives and extracts from Cudrania tricuspidata fruits protect against 6-hydroxydomamine-induced neuronal cell death by enhancing proteasome activity and the ubiquitin/proteasome-dependent degradation of α-synuclein and synphilin-1
The orobol derivatives and CTE 50 inhibit neuronal cell death and ROS generation. The orobol derivatives and CTE 50 protect 6-OHDA-induced proteasome dysfunction. The orobol derivatives and CTE 50 inhibit ubiquitination of α-synuclein, synphilin-1.