Efficient synthesis of N-protected amino/peptide Weinreb amides from T3P and DBU

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• 作者：K.M. Sharnabai ; G. Nagendra ; T.M. Vishwanatha ; Vommina V. Sureshbabu ; ^{sureshbabuvommina@rediffmail.com} ; ^{hariccb@hotmail.com} ; ^{hariccb@gmail.com}
• 关键词：Weinreb amides ; T3P ; DBU ; N¦Á-protected amino/peptide acids
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：6 February, 2013
• 年：2013
• 卷：54
• 期：6
• 页码：478-482
• 全文大小：745 K

文摘

The reaction of N^¦Á-protected amino/peptide acid with N,O-dimethylhydroxylamine hydrochloride in the presence of T3P and DBU to obtain enantiomerically pure N^¦Á-protected amino/peptidyl Weinreb amides in high yields has been described. Fmoc-Ala-Weinreb amide 2a is obtained as single crystal, and its structure was determined through X-ray crystallography.