Facile one-step synthesis of 2,5-diketopiperazines

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• 作者：Xianyu Sun^a ; ^c ; Rachita Rai^a ; Alexander D. MacKerell Jr.^a ; Alan I. Faden^b ; Fengtian Xue^a ; ^b ; ^{fxue@rx.umaryland.edu" class="auth_mail}
• 关键词：Diketopiperazine ; Fmoc deprotection ; Intramolecular cyclization ; Amide formation ; Neuroprotection
• 刊名：Tetrahedron Letters
• 出版年：12 March, 2014
• 年：2014
• 卷：55
• 期：11
• 页码：1905-1908
• 全文大小：730 K

文摘

We report a one-step protocol for the general synthesis of 2,5-diketopiperazines from an Fmoc-protected amino acid and an amino acid ester. The application of the method is highlighted by rapid and efficient preparation of various 2,5-diketopiperazines.