Pharmacological inhibition of PTEN attenuates cognitive deficits caused by neonatal repeated exposures to isoflurane via inhibition of NR2B-mediated tau phosphorylation in rats

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• 作者：Lei Tan^a ; ¹ ; Xin Chen^b ; ¹ ; Wei Wang^c ; Jianfang Zhang^a ; Shiyong Li^a ; Yilin Zhao^a ; Jintao Wang^a ; Ailin Luo^a ; ^{alluo@tjh.tjmu.edu.cn}
• 关键词：Developing brain ; Isoflurane ; NR2B-containing NMDAR ; Phosphatase and tensin homolog deleted on chromosome 10 ; Tau phosphorylation
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：135-145
• 全文大小：2849 K
• 卷排序：114

文摘

Repeated isoflurane exposures result in activation of PTEN in the hippocampus of neonatal rats. Inhibition of PTEN with BPV (pic) reduces cognitive deficits in the rats repeatedly exposed to isoflurane in neonatal age. Inhibition of PTEN restores synaptic protein synthesis and ameliorates tau phosphorylation in the hippocampus. NR2B-containing NMDA receptor acts downstream of PTEN in regulating tau phosphorylation.