Inhibition of chikungunya virus by picolinate that targets viral capsid protein
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- 作者：Rajesh Sharmaa ; Benazir Fatmaa ; Amrita Sahab ; Sailesh Bajpaic ; Srinivas Sistlac ; Paban Kumar Dashb ; Manmohan Paridab ; Pravindra Kumara ; Shailly Tomara ; shailfbt@iitr.ac.in" class="auth_mail" title="E-mail the corresponding author ; shaiprav@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CHIKV ; Chikungunya virus ; NC ; Nucleocapsid ; CVCP ; CHIKV capsid protein ; cdE2 ; Cytoplasmic domain of E2 Glycoprotein ; PCA ; Picolinic acid ; ITC ; Isothermal Titration Calorimetry ; SPR ; Surface Plasmon Resonance ; CP ; Capsid Protein ; PPIs ; protein-protein interactions
- 刊名：Virology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：498
- 期：Complete
- 页码：265-276
- 全文大小：3578 K
文摘
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Picolinic acid (PCA) binds to the hydrophobic pocket of CHIKV capsid protein (CP).
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The binding constant KD (M) obtained for PCA was 2.1×10−7 M.
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PCA inhibits CHIKV replication in Vero cells.
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PCA potentially inhibits CHIKV via targeting protein-protein interactions of the CP.
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Study suggests potential of pyridine ring compounds similar to PCA as antivirals.