What are the structural features that drive partitioning of proteins in aqueous two-phase systems?

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• 作者：Zhonghua Wu^a ; Gang Hu^a ; Kui Wang^a ; Boris Yu. Zaslavsky^b ; ^{boris.zaslavsky@cleveland-diagnostics.com} ; Lukasz Kurgan^c ; ^{lkurgan@vcu.edu} ; Vladimir N. Uversky^d ; ^e ; ^{vuversky@health.usf.edu}
• 关键词：Aqueous two phase system ; Partition ; Protein structure ; Protein structural feature
• 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1865
• 期：1
• 页码：113-120
• 全文大小：442 K
• 卷排序：1865

文摘

The partition of 10 globular proteins in 29 different ATPSs is analyzed 57 structural descriptors are derived from amino acid sequences and crystal structures Partition behavior is accurately determined by a few structural characteristics There is no unique set of structural features for global description of partitioning Protein partition behavior in different ATPSs relies on different structural features