TRAIL-CM4 fusion protein shows in vitro antibacterial activity and a stronger antitumor activity than solo TRAIL protein
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- 作者：Ming Sanga ; c ; Jiaxin Zhangb ; Bin Lic ; libin@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yuqing Chena ; chenyuqing@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRAIL-CM4 fusion protein ; Cells membrane location ; Antitumor activity ; Antibacterial activity ; Function combination
- 刊名：Protein Expression and Purification
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：82-89
- 全文大小：1523 K
文摘
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This is the first report of fusion protein TRAIL-CM4 expression in Escherichia coli.
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TRAIL-CM4 exhibits stronger anti-proliferative activity against tumor cells than solo TRAIL.
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TRAIL-CM4 also induces more tumor cells apoptosis than solo TRAIL.
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TRAIL-CM4 exerts strong antibacterial activity like CM4.