The endosome-to-trans Golgi network (TGN) retrograde trafficking is an important pathway to divert endocytic cargoes from lysosomal degradation.
Common methods in studying the retrograde trafficking are evaluated.
Components involved, such as retromer, small GTPases, coat proteins, SNAREs and tethering factors, are reviewed.
The roles of the retrograde trafficking in signal transduction and diseases are discussed.