From endosomes to the trans-Golgi network
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- 作者：Lei Lua ; lulei@ntu.edu.sg" class="auth_mail ; Wanjin Hongb ; c
- 关键词：AD ; Alzheimer disease ; AP1 ; adaptor protein 1 ; APP ; amyloid precursor protein ; BAR ; Bin/Amphiphysin/Rvs ; CD-M6PR ; cation-dependent mannose-6-phosphate receptor ; CI-M6PR ; cation-independent mannose-6-phosphate receptor ; COG ; conserved oligomeric Golgi complex ; GRIP ; Golgin97-RanBP-Imh1p-p230 trans Golgi protein ; CTxB ; Cholera toxin B fragment ; EE ; early endosome ; EHD1 ; eps15 homology domain 1 ; EpsinR ; Epsin related protein ; ER ; endoplasmic reticulum ; FKBP ; FK506 binding protein ; FRB ; FKBP rapamyc
- 刊名：Seminars in Cell and Developmental Biology
- 出版年：July 2014
- 年：2014
- 卷：31
- 期：Complete
- 页码：30-39
- 全文大小：1917 K
文摘
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The endosome-to-trans Golgi network (TGN) retrograde trafficking is an important pathway to divert endocytic cargoes from lysosomal degradation.
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Common methods in studying the retrograde trafficking are evaluated.
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Components involved, such as retromer, small GTPases, coat proteins, SNAREs and tethering factors, are reviewed.
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The roles of the retrograde trafficking in signal transduction and diseases are discussed.