CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling
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- 作者：Nicla PorcielloAuthor Vitae ; Loretta Tuosto ; loretta.tuosto@uniroma1.it" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：MHC ; major histocompatibility complex ; TCR ; T-cell receptor ; APC ; antigen presenting cell ; Ig ; immunoglobulin ; IL ; interleukin ; IS ; immunological synapse ; PLCγ1 ; phospholipase Cγ1 ; LAT ; linker for activation of T cells ; Grb2 ; growth-factor receptor-bound protein ; GADS ; Grb2-related adaptor downstream of Shc ; PKCθ ; protein kinase C θ ; ERK ; extracellular signal regulated kinases ; JNK ; jun N-terminal kinases ; NF-AT ; nuclear factor of activated T cells ; NF-κB ; nuclear factor-κB ; AP-1 ; activator prot
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：28
- 期：Complete
- 页码：11-19
- 全文大小：1339 K
文摘
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CD28 costimulatory signals are essential for T lymphocyte activation.
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CD28 is a crucial regulator of actin cytoskeleton reorganization.
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Actin cytoskeleton regulating proteins couple CD28 to NF-κB activation.
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Human CD28 delivers TCR-independent pro-inflammatory signals.
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The C-terminal proline rich motif regulates human CD28 unique pro-inflammatory functions.