Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue
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- 作者：Wenjun Zhaoa ; Aiyun Lib ; c ; Xin Fenga ; Ting Houa ; Kang Liub ; c ; Baolin Liub ; c ; Ning Zhanga ; ningzh18@yeah.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：FFAs ; free fatty acids ; HFD ; high-fat diet ; HIF-1α ; hypoxia inducible factor-1α ; VEGF ; vascular endothelial growth factor ; Glut1 ; glucose transporter 1 ; DAG ; diacylglycerol ; PKCθ ; protein kinase Cθ ; PDE3B ; phosphodiesterase 3B ; cAMP ; cyclic AMP
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1401-1411
- 全文大小：2746 K
文摘
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Short-term high fat diet feeding induces hypoxia with inflammation in adipose tissue.
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FFAs influx and lipid deposition induce insulin resistance in muscle.
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Metformin and resveratrol prevent lipolysis-induced insulin resistance.