Truncated prion protein PrP226* - A structural view on its role in amyloid disease

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• 作者：Valerija Kovač^a ; ^{valerija.kovac@ztm.si} ; Blaž Zupančič^b ; Gregor Ilc^b ; ^c ; Janez Plavec^b ; ^c ; ^d ; Vladka Čurin &Scaron ; erbec^a
• 关键词：Prion protein ; Stop mutation ; Truncation ; NMR structure
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：45-50
• 全文大小：1159 K
• 卷排序：484

文摘

Truncation at C-terminus results in pathological properties of prion protein. Structure reveals a break in C-terminal helix and disorder in β2−α2 loop region. Presence of reorganized hydrophobic interactions between helix α3 and β2−α2 loop.