Visualization of prion-like transfer in Huntington's disease models

详细信息    查看全文

• 作者：Anne H.P. Jansen^a ; Kevin L. Batenburg^a ; Eline Pecho-Vrieseling^b ; Eric A. Reits^a ; ^{e.a.reits@amc.uva.nl}
• 关键词：Prion ; Huntington ; Aggregation ; Microscopy ; Neurodegeneration
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1863
• 期：3
• 页码：793-800
• 全文大小：1174 K
• 卷排序：1863

文摘

Prion-like spreading of mHTT occurs in vitro and in vivo. Fluorescence-tagged proteins are a power tool for the visualization of mHTT transfer. mHTT cell-to-cell transfer can take place via several mechanisms.