Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells
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- 作者：Cara Jamiesona ; Kate M. Millsa ; Christina Luia ; Crystal Semaana ; b ; Mark P. Molloyb ; Manisha Sharmaa ; 1 ; Jade K. Forwoodc ; Beric R. Hendersona ; beric.henderson@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：APC ; adenomatous polyposis coli ; Beta-COP ; coatomer protein beta-subunit ; COP ; Coat protein complex ; LEF-1 ; Lymphoid enhancer factor 1 ; TCF ; T-cell factor
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：341
- 期：2
- 页码：196-206
- 全文大小：4646 K
文摘
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MCF-7 breast cancer cells are defective for beta-catenin nuclear accumulation.
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10">Beta-catenin nuclear retention is lost in MCF-7 cells due to poor LEF1/TCF expression.
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15">Beta-catenin accumulates in the cytoplasm at endosomes and golgi in MCF-7 cells.
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Wnt signaling can stimulate release of beta-catenin from endosomes.