Analysis of Mitochondrial haemoglobin in Parkinson's disease brain
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- 作者：Freya Shepharda ; Oliver Greville-Heygatea ; Susan Liddellb ; Richard Emesa ; Lisa Chakrabartia ; lisa.chakrabarti@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pcd5j ; Purkinje Cell Degeneration mouse strain 5j ; PM ; post mortem ; HbA ; alpha haemoglobin ; HbB ; beta haemoglobin ; BSA ; bovine serum albumin ; TBS-T ; tris buffered saline&ndash ; tween ; COXIV ; cytochrome c oxidase IV ; HSP90 ; heat shock protein 90 ; VDAC ; voltage dependent anion channel ; NDUFS3 ; NADH dehydrogenase ubiquinone FeS ; SMAC ; second mitochondrial activator of caspase
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：29
- 期：Complete
- 页码：45-52
- 全文大小：1730 K
文摘
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Intracellular Haemoglobin changes mitochondrial localisation in response to environmental cues such as hypoxia and Parkinson’s disease.
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There are molecular changes in mitochondria extracted from the cerebellum of Parkinson’s Disease brain.
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We find that mitochondrial Hb may be regulated differently according to gender.