Sample-dependent diagnostic accuracy of prostaglandin D synthase in cerebrospinal fluid leak

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• 作者：Daniel Morell-Garcia^a ; ^b ; ^{dr.morell.uab@gmail.com} ; Josep Miquel Bauç ; a^a ; ^b ; M. Pilar Sastre^a ; Aina Yañ ; ez^b ; Isabel Llompart^a
• 关键词：Beta-trace protein ; Cerebrospinal fluid leak ; Cut-off ; Nephelometry ; Rhinorrhea
• 刊名：Clinical Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：50
• 期：1-2
• 页码：27-31
• 全文大小：389 K
• 卷排序：50

文摘

Prostaglandin D2 synthase is an excellent biomarker for the assessment of cerebrospinal fluid leaks. Maybe the most appropriate cut-off value used for rhinorrhea and otorrhea samples was 0.7 mg/L. Values greater than 2.0 mg/L could be used for spine postoperative fluid leakage samples. The cut off value for βTP in the diagnosis and follow-up of cerebrospinal fluid leaks should be modified depending on the type of secretion (sample type), for a better diagnostic accuracy.