Origin and Functional Evolution of the Cdc48/p97/VCP AAA + Protein Unfolding and Remodeling Machine
详细信息 查看全文
- 作者：Dominik Barthelme1 ; 2 ; Robert T. Sauer1 ;
- 关键词：AAA ; + machine ; protein remodeling ; human disease
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：8 May 2016
- 年：2016
- 卷：428
- 期：9
- 页码：1861-1869
- 全文大小：837 K
文摘
- •
Eukaryotic Cdc48 plays essential roles in many ubiquitin-dependent cellular processes.
- •
A large variety of adaptor proteins regulate Cdc48's diverse biological functions.
- •
Archaeal Cdc48 functions with the 20S proteasome in ATP-dependent protein degradation.
- •
Mechanistic models for client protein unfolding and remodeling by Cdc48 are discussed.