Myristic acid is associated to low plasma HDL cholesterol levels in a Mediterranean population and increases HDL catabolism by enhancing HDL particles trapping to cell surface proteoglycans in a liver hepatoma cell model
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- 作者：Davide Noto1 ; Francesca Fayer1 ; Angelo B. Cefalù ; Ida Altieri ; Ornella Palesano ; Rossella Spina ; Vincenza Valenti ; Maria Pitrone ; Giuseppe Pizzolanti ; Carlo M. Barbagallo ; Carla Giordano ; Maurizio R. Averna ; avernam@mbox.unipa.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fatty acids ; Population study ; HDL cholesterol levels ; HepG2 cells
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：246
- 期：Complete
- 页码：50-56
- 全文大小：566 K
文摘
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Plasma free fatty acids were correlated with HDL-C in a Sicilian population.
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Myristic acid resulted inversely correlated with HDL-C levels.
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Effects of fatty acids on HDL binding to hepatoma cells were evaluated “in vitro”.
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Myristic acid increased HDL binding by increasing cells proteoglycan matrix.