Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues
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- 作者：Shiho Takeuchia ; Shin-Ichi Nakanoa ; Katsuyuki Nakamuraa ; Atsufumi Ozoeb ; Peggie Chienc ; Hidehito Yoshiharab ; d ; Fumihiko Hakunob ; Takashi Matsuwakia ; Yasushi Saekid ; Shin-Ichiro Takahashib ; Keitaro Yamanouchia ; akeita@mail.ecc.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masugi Nishiharaa
- 关键词：ACTA2 ; α-actin 2 ; α-SMA ; α-smooth muscle actin ; bFGF ; basic fibroblast growth factor ; Col1a1 ; collagen type 1 ; CSPG4 ; chondroitin sulfate proteoglycan 4 ; CTGF ; connective tissue growth factor ; FAPs ; fibro/adipogenic progenitors ; FGFR ; fibroblast growth factor receptor ; HPRT ; hypoxanthine-guanine phosphoribosyltransferase ; IMAT ; intramuscular adipose tissue ; LC-MS/MS ; Liquid chromatography-tandem mass spectrometry ; mAb ; monoclonal antibody ; MPCs ; mesenchymal progenitor cells ; PBS ; phosphate-buffe
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：347
- 期：2
- 页码：367-377
- 全文大小：3084 K
文摘
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We produced monoclonal antibodies that bind to rat MPC cell surface antigens.
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The monoclonal Ab 5C12 recognized chondroitin sulfate proteoglycan 4.
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CSPG4 was required for the pro-adipogenic effects of bFGF.
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CSPG4 mediates αSMA expression and stress fiber formation induced by TGF-β.