Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination
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- 作者：Lotta E. Oikari ; Rachel K. Okolicsanyi ; Aro Qin ; Chieh Yu ; Lyn R. Griffiths ; Larisa M. Haupt ; larisa.haupt@qut.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neural stem cell ; Differentiation ; Heparan sulfate proteoglycan ; Syndecan ; Glypican
- 刊名：Stem Cell Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：16
- 期：1
- 页码：92-104
- 全文大小：2667 K
文摘
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hNSC H9 cells maintain self-renewal and multipotent capacity during long-term culture.
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hNSC H9 cells express HS biosynthesis enzymes and cell surface HSPGs.
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Lineage commitment alters hNSC H9 cell HSPGs profile.
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Glypican 1 and 4 mediate hNSC H9 lineage differentiation potential.
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Syndecans and glypicans provide novel markers of hNSCs and neural cells.