The heparanase/heparan sulfate proteoglycan axis: A potential new therapeutic target in sarcomas
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- 作者：Giuliana Cassinelli ; giuliana.cassinelli@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Nadia Zaffaroni ; Cinzia Lanzi
- 关键词：Heparan sulfate proteoglycan ; Heparanase ; Heparanase inhibitor ; Heparan sulfate mimetic ; Sarcoma
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 November 2016
- 年：2016
- 卷：382
- 期：2
- 页码：245-254
- 全文大小：2042 K
文摘
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The heparanase/HSPG system is a critical player in tumor growth and progression.
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Heparanase expression is associated with aggressiveness and poor prognosis in various sarcomas.
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Expression of specific HSPGs is deregulated in specific sarcoma subtypes.
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Heparanase/HSPG-dependent signaling pathways are deregulated in sarcoma subtypes.
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The heparanase/HSPG axis represents an attractive therapeutic target in sarcomas.