刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:February 2017
年:2017
卷:1863
期:2
页码:509-517
全文大小:2384 K
卷排序:1863
文摘
SP-A is up-regulated in mouse and human kidney epithelium with ureter obstruction. SP-A deficiency exacerbates UUO-caused kidney structural damage and fibrosis in mice. SP-A inhibits HMGB1-mediated myofibroblast activation. SP-A attenuates HMGB1-induced TGF-β expression. SP-A physically interacts with HMGB1.