Pathophysiology, research challenges, and clinical management of smoke inhalation injury

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• 作者：Prof Perenlei Enkhbaatar ; MD^a ; ^{peenkhba@utmb.edu" class="auth_mail" title="E-mail the corresponding author} ; Prof Basil A Pruitt Jr ; MD^c ; Prof Oscar Suman ; PhD^b ; ^d ; Ronald Mlcak ; PhD^d ; ^e ; Prof Steven E Wolf ; MD^f ; Prof Hiroyuki Sakurai ; MD^g ; Prof David N Herndon ; MD^b ; ^d
• 刊名：The Lancet
• 出版年：2016
• 出版时间：1-7 October 2016
• 年：2016
• 卷：388
• 期：10052
• 页码：1437-1446
• 全文大小：1181 K

文摘

Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.