Nanoencapsulation of gallic acid and evaluation of its cytotoxicity and antioxidant activity
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- 作者：Aline de Cristo Soares Alves ; Rubiana Mara Mainardes ; Najeh Maissar Khalil najehunicentro@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nanoparticles ; Gallic acid ; Hemolysis ; Antioxidant
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：126-134
- 全文大小：1215 K
文摘
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Galli acid (GA) was nanoencapsulated in poly(lactide-co-glycolide) (PLGA) nanoparticles.
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Influence of polysorbate 80 (PS80) coating in nanoparticles parameters was evaluated.
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Mean particle size was 220 nm and GA encapsulation efficiency was around 25%.
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PLGA nanoparticles containing GA presented a very negligible hemolysis, but not PS80 coated nanoparticles.
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PS80 coating decreased the antioxidant activity of GA.