Buccal viral DNA as a trigger for brincidofovir therapy in the mousepox model of smallpox

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• 作者：Ryan Crump^a ; ¹ ; Maria Korom^b ; ¹ ; R. Mark Buller^a ; Scott Parker^a ; ^{scott9379@gmail.com}
• 关键词：Ectromelia ; Variola virus ; Antiviral ; Viral DNA ; Brincidofovir ; CMX001
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：139
• 期：Complete
• 页码：112-116
• 全文大小：773 K
• 卷排序：139

文摘

Brincidofovir effectively protected large numbers (n = 15) of mice against a lethal ectromelia virus challenge. Buccal swabs were selected as a non-invasive mechanism to sample mice for a biomarker (vDNA) of disease. vDNA in buccal swabs can be detected within the therapeutic window of brincidofovir.