Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors
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- 作者：Alexandra E. Smitha ; Zhili Xua ; b ; Yvonne Y. Laia ; c ; Pushkar M. Kulkarnid ; Ganesh A. Thakurd ; Andrea G. Hohmanna ; b ; Jonathon D. Crystala ; jcrystal@indiana.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Source memory ; Spatial memory ; Episodic memory ; NMDAR ; MK-801 ; PSD95-nNOS small molecule inhibitors
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：23-29
- 全文大小：925 K
文摘
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Source memory was more vulnerable than spatial memory to impairment in rats.
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NMDAR antagonist MK-801 preferentially impaired source memory over spatial memory.
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PSD95-nNOS inhibitors failed to produce spatial memory or source memory impairments.
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IC87201 and ZL006 disrupt NMDA-stimulated formation of nitric oxide in vitro.
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PSD95-nNOS disruptors may lack unwanted side effects of NMDAR antagonists.