Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9

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• 作者：Beibei Zhou ; Jun Leng ; Meng Hu ; Li Zhang ; Zhan Wang ; Dongying Liu ; Xiaoling Tong ; Beibei Yu ; Yi Hu ; Chaohua Deng ; Yanping Liu ; Qiuping Zhang
• 关键词：Ezrin ; Polarization ; MOLT4 cell ; Metastasis ; CCL25/CCR9 ; ERM
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：34
• 期：6
• 页码：769-776
• 全文大小：1242 K

文摘

Chemokines and their corresponding receptors participate in transmigration of leukemic cells. ERM (ezrin/radixin/moesin) protein family act as linkers between the plasma membrane and the cytoskeleton and are key component in tumor metastasis. In this study we used the CCR9-expressing acute T lymphocytic cell line MOLT4 as a model and assesssed their morphological and functional changes in response to CCL25. The pseudopodium formed and ERM translocated from the cytoplasm to the cell membrane following treatment with CCL25. Ezrin silencing by miRNA showed that ezrin plays important roles in the polarization and invasive behaviour of MOLT4 cells.