Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi)
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- 作者：Xin-Xin Wanga ; b ; 1 ; Xia Lvb ; 1 ; Shi-Yang Lib ; Jie Houc ; Jing Ningb ; c ; Jia-Yue Wangb ; Yun-Feng Caoa ; b ; Guang-Bo Geb ; geguangbo@dicp.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Bin Guoa ; jyguobin@126.com" class="auth_mail" title="E-mail the corresponding author ; Ling Yangb ; d
- 关键词：Fructus psoraleae ; LC-UV fingerprint ; UDP-glucuronosyltransferase 1A1 ; Inhibitory effects ; NCHN
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：289
- 期：1
- 页码：70-78
- 全文大小：1046 K
文摘
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A method for rapid identification of UGT1A1 inhibitors from herbals was developed.
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Fructus psoraleae (FP) extract displayed strong inhibitory effects on UGT1A1.
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Five UGT1A1 inhibitory constituents in FP were identified for the first time.
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The inhibition mechanism and the inhibition constant were well-characterized.